Generic name:

　　Milnacipran Hydrochloride Tablets

　　Functional indications:

　　It is suitable for patients with depression.

　　Usage and dosage:

　　Adults: the initial dose is 50mg daily, gradually increasing to 100mg daily, 2~3 times a day, after meals. According to the doctor's advice, the dosage can be increased or reduced according to age and symptoms.

　　Dosage forms:

　　tablet

　　Side effects:

　　Adverse reactions mainly occurred in the first week of taking Minapram, which lasted until the second week, then gradually weakened and depressive symptoms improved. Adverse reactions are generally mild and rarely require stopping treatment. The most common adverse reactions were vertigo, sweating, anxiety, fever and dysuria when used alone or in combination with other psychotropic drugs. Significant adverse reactions requiring special attention are: Syndrome Malin (incidence less than 0.1%): hypokinesia, high muscle stiffness, dysphagia, tachycardia, blood pressure changes, sweating and other adverse reactions, followed by persistent fever of malignant syndrome. When the symptoms occur, the drug should be stopped, and appropriate measures such as lowering body temperature and replenishing water should be taken. 2) Serotonin Syndrome (Incidence rate is unknown): Because of serotonin syndrome: irritation, confusion, sweating, hallucination, hyperreflexia, myoclonus, tremor, tachycardia, tremor, fever, abnormal coordination and other symptoms, should stop taking medication, take appropriate measures to reduce body temperature, supplement water and so on. 3) Spasm (incidence less than 0.1%): When abnormal conditions occur due to spasm, drug administration should be stopped and appropriate treatment should be adopted. 4) Leukopenia (the incidence is unknown): Leukopenia may be caused, so blood tests should be carried out at any time, once abnormal is found, drug administration should be stopped, and appropriate measures should be taken to deal with it. 5) Severe skin injury (the incidence is unknown): may cause serious skin injury such as skin mucosal eye syndrome (Stevens-Johnson syndrome), so we should fully observe, once there is fever, erythema, itching, eye congestion, stomatitis, etc., should stop taking drugs, adopt appropriate methods to deal with. 6) SIADH: It may cause hyponatremia, hypoosmolality, hypernatremia, hypertonia and disturbance of consciousness.

　　When symptoms such as loss of appetite, headache, belching, vomiting and general fatigue occur, electrolyte tests should be carried out. If abnormalities are found, appropriate measures such as stopping administration and limiting water intake should be taken. 7) Liver dysfunction and jaundice (incidence less than 0.1%): As AST (GOT), ALT (GPT), and gamma-GPT increase, it can cause liver dysfunction and jaundice, so close observation should be made. Once abnormalities are found, drug withdrawal should be immediately and appropriate treatment should be adopted. General adverse reactions: nausea, vomiting, dry mouth, constipation, tremor, palpitation, restlessness, headache, urticaria, rash, macula or erythema, pruritus. It is important to remind patients with cardiovascular disease or concurrent cardiac therapy that common adverse cardiovascular reactions may be aggravated (e.g. hypertension, hypotension, orthostatic hypotension, tachycardia or palpitation).

　　Taboos:

　　Mina F Leon is known to be allergic.

　　Matters needing attention:

　　1. Caution should be given to the following patients:

　　(1) Patients with dysuria or a history of dysuria (because the drug can inhibit norepinephrine re-uptake and worsen the condition). )

　　(2) Glaucoma, or elevated intraocular pressure (because the drug can inhibit norepinephrine re-uptake, can worsen the condition). )

　　(3) Patients with hypertension or heart disease (because the drug has the effect of increasing blood pressure and accelerating heart rate, which can make the condition worse. )

　　(4) patients with liver disease (sustained high concentration in the blood). )

　　(5) Patients with kidney diseases (in vivo pharmacokinetic tests conducted by patients with renal dysfunction abroad confirm that the drug has a tendency to maintain a high concentration in the blood, so it should be reduced appropriately. )

　　(6) patients with convulsive seizures or history of epilepsy can cause convulsions. )

　　(7) bipolar disorder (manic and suicidal attempts). )

　　(8) Patients with suicidal ideation or attempted suicide in the past and those with suicidal ideation (showing suicidal ideation or attempted suicide)

　　(9) patients with organic brain damage or coordination disorder (worsening mental symptoms). )

　　(10) Patients with haemostatic disorders should be cautious when taking anticoagulants and drugs that affect platelet function (such as NSAIDs, aspirin and other drugs that may increase bleeding tendency).

　　2. important points for attention

　　(1) For patients with depressive symptoms who have death thoughts and suicidal tendencies, the patients'state and symptoms should be closely observed at the initial stage of administration and when the dosage changes. If there are new self-injury, emotional fluctuation, psychomotor instability and emotional instability, or when such symptoms deteriorate, we should stop increasing dosage, gradually reduce dosage, stop medication and other appropriate treatment methods.

　　(2) In order to prevent suicidal overdose, the number of prescription days per prescription should be kept to a minimum for suicidal patients.

　　(3) the risk of suicidal thoughts and suicide attempts should be fully informed to the family members of the patients. Instruct family members to maintain close contact with doctors.

　　(4) Patients who are taking this medicine because of sleepiness and vertigo may not engage in dangerous mechanical operations such as driving a car.

　　Ingredients:

　　The main ingredient is Mina F Leon hydrochloride. his